Source [1], page 193, Section #8. Ann Drusilla's parents and siblings:
"Andrew Van Sickle, the third child of Peter and Catherine was born in Sussex County, New Jersey, about the year 1779. He was married in the same county, on the 8th of Sept., 1800 to Sarah, daughter of Solomon Courtright, of Sussex County, New Jersey, by whom he had thirteen children. ...    (My note: two of them died young.)

In the autumn of 1817, he emigrated to Southern Ohio, and settled in Gallia County, where he remained about three years, thence removing to Indiana and settling in Vermillion County, where he resided until his death, which occurred July 17, 1822 or August 24, 1824. ...

His wife, Sarah, ... . In 1827 she removed to Jo Daviess County, Illinois, where she resided until her death, which occurred in September, 1849."

Dr. Van Sickle's 1880 book has been quoted often because there is no other source for much of the information that it contains. He lived in Springfield, Ohio and was unable to travel to all the Van Sickle households to do in-person interviews. He solicited information by mail  from family members who were scattered far and wide. 

In the Preface to his book, Dr. Van Sickle wrote, "The completeness of a work of this  character, evidently depends largely upon the kindness and courtesy of those from whom the solicited material must be obtained."  

Notice also in the Preface, Dr. Van Sickle credits several people with providing family information to him. He also reminds us "in many instances, dates and information received from one member of a family would conflict with those received from another member of the same family; while in other cases dates received from the same person at different times would conflict with each other." 

The source of some, if not all information for the Andrew and Sarah Van Sickle branch of the family was credited to De Witt Clinton Van Sickle of Elkader, Clayton County, Iowa, the ninth child of Andrew and Sarah. He was an older brother of Ann Drusilla. De Witt Clinton would have been 62 or 63 at the time of his communications with Dr. Van Sickle. 

Dr. Van Sickle's book includes a numbered paragraph for each of the 11 children of Andrew and Sarah Van Sickle living at that time.   You can find them in sections #28 through #39 beginning on page 189. Most of them were (or had been) living in Iowa or just across the Mississippi River in Wisconsin at the time of Dr. Van Sickle's 1880 book.

I've enjoyed studying Dr. Van Sickles book A busy man such as he, who would take the time to compile such a book as his, certainly deserves our respect and admiration. But of all his writings, there is one paragraph that I do not understand. That paragraph, quoted below, has been on my mind from the first day that I read it, months ago.    

Regarding the family movements from 1815 to Andrew's death in 1822, we can follow them from New York to Indiana using the birth information in Dr. Van Sickle's book:
                       #36. Moses E. was born July 6, 1815 in New York.
                       #37. Sarah Ann was born February 4, 1818 in Ohio.
                      #38. Ursula was born February 16, 1820 in Indiana.
                      #39. Ann Drusilla was born August 19, 1822 in Indiana.
Then the text leads one to believe that Andrew died in Vermillion County, Indiana on July 17, 1822, or August 24, 1824, then in 1827, his wife Sarah,  moved to Jo Daviess County, Illinois where she resided until her death in September of 1849.

From the "Zilla and Ila  Manuscript" [4] page 4, para 15: "Our grandmother Ann Drusilla Van Sickle Dickens was born in August 1822. Her father had died of typhus fever during the early spring, therefore she was a posthumous child." (My note: that statement answers the question of whether Andrew Van Sickle died in 1822 or 1824. See para 71 below.)

Continuing para 15, Andrew's death: "This was at Cairo, Illinois, which we must recall was at that time an important river port town at the confluence of the Ohio and Mississippi Rivers. Seaborne plagues such as typhus came up the Mississippi from the Gulf of Mexico on boats which had been in contact with deep sea shipping."  (My note: What? Andrew died in Cairo, Illinois and not in Vermillion County, Indiana? Cairo is way down southwest of Vermillion County, Indiana, on a little peninsula between the Ohio  River and the state of Kentucky on one side and the Mississippi River and the state of Missouri on the other side. That's about 175 miles from Vermillion County, Indiana 'as the crow flies' - even further following overland  trails or the river - a long, tiresome journey in those days.)

Continuing on page 21, para 71: "She (Sarah) was my grandmother's mother, widowed five months before Grandma was born---her husband Andrew Van Sickle died in a typhus epidemic at Cairo, Illinois, in April 1821." (My note: he died in 1822 as written in the first part of para 15 above - about four months before Ann was born in 1822.)

Andrew's death, Ann Drusilla's birth.

In her "Reminiscences" [3] last sentence, Ann confirms: " I was born in Indiana but moved westward ... ."

If Andrew died in Cairo, Illinois in 1822, one thing is sure: he had not moved the family to Cairo.
There was no city there. An attempt to organize a city there failed in 1818 and the city wasn't organized until 1837.

Here's what John M. Lansden wrote in his 1910 'A History of the City of Cairo, Illinois'  pp 39-40, (available on Google): " to Cairo, it was a mere wood-yard, at which the steamboats would land to take on wood for their furnace fires, and then proceed on their journeys up or down the rivers ... there were trading boats, which, while trading very little at the point, found it a convenient place to stop for a time; for while there was no town here, or anything resembling one, the point was a central one, a kind of half-way house, at which one would tarry a while before starting out on a long river journey northward, eastward, or southward."

I've wondered why Andrew was in Cairo? Also, did he have some of his older boys with him?He could have been buying or selling merchandise or working in the area. Dr Van Sickle wrote: "He (Andrew) was a farmer, wheelwright, and shoemaker by occupation." Shoes, wagon wheels, and food products would have been very important to the business of  keeping the riverboats supplied. 

Thus ends the life of Andrew Van Sickle in the spring of 1822 at Cairo, Illinois. His age was
about 43. Sarah, at home in Vermillion County, Indiana, was about 38. They had been married almost 22 years. Now she was a widow with ten children, the oldest about 19, the youngest about 2 and Ann Drusilla, number eleven, was on the way - born on August 19, 1822.

I wonder if Andrew was transported back to Vermillion County, Indiana or buried someplace near Cairo?

Summary of this page.
Andrew Van Sickle  b. ca 1779, Sussex County, New Jersey.   d. Spring of 1822 at Cairo, Illinois of a sickness while on a visit there from his home in Vermillion County, Indiana.

Andrew was married in Sussex County September 8, 1800 to Sarah Courtright, b 1784 (from 1850 census) d (unknown to me at this time) daughter of Solomon Courtright of Sussex County. They were parents of thirteen children, two of whom died young. (There will be more about Sarah Courtright Van Sickle on the following pages.)

At the time of his death in the spring of 1822, his widow Sarah was left with the following children:
# is the paragraph number for this person as listed in Dr.Van Sickle's book.

#28. Thomas, b. May 10, 1803 in NJ, age about 19.
#29. Jacob, b. January 3, 1805, born in a boat on the Mohawk River, age about 17.
#30. Martin, b. December 10, 1806 in NY, age about 16.
#31. Hannah, b. September 12, 1808 in NY, age about 14.
#32. Eliza, b. April 14, 1810 in NY, age about 12.
#33. Almira, b. June 8, 1812 in NY, age about 10.
#35. Sergeant De Witt Clinton, b. March 16, 1816 in NY, age about 6.
#36. Moses E., b. July 6, 1815 in NY, age about 7.
#37. Sarah Ann, b. February 4, 1818 in Ohio, age about 4.
#38. Ursula, b. February 16, 1820 in IN, age about 2.
#39. Ann Drusilla was not born until August 19, 1822 in IN - after her father died.

The reversal of age/position for #35 and #36 is the way it's numbered in the book.
I haven't found any information about how many of these were still living at home at the time of Andrew's death in 1822 but by the late 1820's several had gone to the Lead Mining District in
Wisconsin and Illinois.

Andrew and Sarah Van Sickle 
   from about 1815 to 1822
Page 02.
Page 02.
Sarah Courtright Van Sickle Redmond
        A Northeast Iowa Pioneer